Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe authors disscuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation.
[International Journal of Molecular Sciences]
6445212 42CXBXCX items 1 apa 0 default asc 1 160995 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d743a8aa8db8dbaf089ff510a41d2fb2%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2242CXBXCX%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Magatti%20et%20al.%22%2C%22parsedDate%22%3A%222021-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMagatti%2C%20M.%2C%20Masserdotti%2C%20A.%2C%20Cargnoni%2C%20A.%2C%20Papait%2C%20A.%2C%20Stefani%2C%20F.%20R.%2C%20Silini%2C%20A.%20R.%2C%20%26amp%3B%20Parolini%2C%20O.%20%282021%29.%20The%20Role%20of%20B%20Cells%20in%20PE%20Pathophysiology%3A%20A%20Potential%20Target%20for%20Perinatal%20Cell-Based%20Therapy%3F%20%3Ci%3EInternational%20Journal%20of%20Molecular%20Sciences%3C%5C%2Fi%3E%2C%20%3Ci%3E22%3C%5C%2Fi%3E%287%29%2C%203405.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijms22073405%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijms22073405%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D42CXBXCX%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20Role%20of%20B%20Cells%20in%20PE%20Pathophysiology%3A%20A%20Potential%20Target%20for%20Perinatal%20Cell-Based%20Therapy%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marta%22%2C%22lastName%22%3A%22Magatti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alice%22%2C%22lastName%22%3A%22Masserdotti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Cargnoni%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Papait%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francesca%20Romana%22%2C%22lastName%22%3A%22Stefani%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonietta%20Rosa%22%2C%22lastName%22%3A%22Silini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ornella%22%2C%22lastName%22%3A%22Parolini%22%7D%5D%2C%22abstractNote%22%3A%22The%20pathophysiology%20of%20preeclampsia%20%28PE%29%20is%20poorly%20understood%3B%20however%2C%20there%20is%20a%20large%20body%20of%20evidence%20that%20suggests%20a%20role%20of%20immune%20cells%20in%20the%20development%20of%20PE.%20Amongst%20these%2C%20B%20cells%20are%20a%20dominant%20element%20in%20the%20pathogenesis%20of%20PE%2C%20and%20they%20have%20been%20shown%20to%20play%20an%20important%20role%20in%20various%20immune-mediated%20diseases%2C%20both%20as%20pro-inflammatory%20and%20regulatory%20cells.%20Perinatal%20cells%20are%20defined%20as%20cells%20from%20birth-associated%20tissues%20isolated%20from%20term%20placentas%20and%20fetal%20annexes%20and%20more%20specifically%20from%20the%20amniotic%20membrane%2C%20chorionic%20membrane%2C%20chorionic%20villi%2C%20umbilical%20cord%20%28including%20Wharton%5Cu2019s%20jelly%29%2C%20the%20basal%20plate%2C%20and%20the%20amniotic%20fluid.%20They%20have%20drawn%20particular%20attention%20in%20recent%20years%20due%20to%20their%20ability%20to%20modulate%20several%20aspects%20of%20immunity%2C%20making%20them%20promising%20candidates%20for%20the%20prevention%20and%20treatment%20of%20various%20immune-mediated%20diseases.%20In%20this%20review%20we%20describe%20main%20findings%20regarding%20the%20multifaceted%20in%20vitro%20and%20in%20vivo%20immunomodulatory%20properties%20of%20perinatal%20cells%2C%20with%20a%20focus%20on%20B%20lymphocytes.%20Indeed%2C%20we%20discuss%20evidence%20on%20the%20ability%20of%20perinatal%20cells%20to%20inhibit%20B%20cell%20proliferation%2C%20impair%20B%20cell%20differentiation%2C%20and%20promote%20regulatory%20B%20cell%20formation.%20Therefore%2C%20the%20findings%20discussed%20herein%20unveil%20the%20possibility%20to%20modulate%20B%20cell%20activation%20and%20function%20by%20exploiting%20perinatal%20immunomodulatory%20properties%2C%20thus%20possibly%20representing%20a%20novel%20therapeutic%20strategy%20in%20PE.%22%2C%22date%22%3A%222021%5C%2F1%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fijms22073405%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F1422-0067%5C%2F22%5C%2F7%5C%2F3405%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-07T23%3A40%3A49Z%22%7D%7D%5D%7D
Magatti, M., Masserdotti, A., Cargnoni, A., Papait, A., Stefani, F. R., Silini, A. R., & Parolini, O. (2021). The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy? International Journal of Molecular Sciences, 22(7), 3405. https://doi.org/10.3390/ijms22073405 Cite
