Despite the phenotypic and transcriptional similarities between cord blood and adult macrophages, cord blood cells were prone to viral replication when infected with HIV-1.
[Journal of Infectious Diseases]
6445218 9JDH39RK items 1 apa 0 default asc 1 165533 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-ca9634122d421da8c0bcd6d51b80c9ab%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229JDH39RK%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pietrobon%20et%20al.%22%2C%22parsedDate%22%3A%222021-08-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPietrobon%2C%20A.%20J.%2C%20Yoshikawa%2C%20F.%20S.%20Y.%2C%20Oliveira%2C%20L.%20M.%2C%20Pereira%2C%20N.%20Z.%2C%20Matozo%2C%20T.%2C%20de%20Alencar%2C%20B.%20C.%2C%20Duarte%2C%20A.%20J.%20S.%2C%20%26amp%3B%20Sato%2C%20M.%20N.%20%282021%29.%20Antiviral%20Response%20Induced%20by%20TLR7%5C%2FTLR8%20Activation%20Inhibits%20HIV-1%20Infection%20in%20Cord%20Blood%20Macrophages.%20%3Ci%3EThe%20Journal%20of%20Infectious%20Diseases%3C%5C%2Fi%3E%2C%20%3Ci%3Ejiab389%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjiab389%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjiab389%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3D9JDH39RK%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Antiviral%20Response%20Induced%20by%20TLR7%5C%2FTLR8%20Activation%20Inhibits%20HIV-1%20Infection%20in%20Cord%20Blood%20Macrophages%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20J%22%2C%22lastName%22%3A%22Pietrobon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22F%5Cu00e1bio%20S%20Y%22%2C%22lastName%22%3A%22Yoshikawa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luana%20M%22%2C%22lastName%22%3A%22Oliveira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natalli%20Z%22%2C%22lastName%22%3A%22Pereira%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tais%22%2C%22lastName%22%3A%22Matozo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruna%20C%22%2C%22lastName%22%3A%22de%20Alencar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alberto%20J%20S%22%2C%22lastName%22%3A%22Duarte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20N%22%2C%22lastName%22%3A%22Sato%22%7D%5D%2C%22abstractNote%22%3A%22Vertical%20transmission%20is%20the%20main%20mechanism%20of%20HIV-1%20infection%20in%20infants%2C%20who%20may%20develop%20high%20viremia%20and%20rapidly%20progress%20to%20AIDS.%20Innate%20immunity%20agonists%20can%20control%20HIV-1%20replication%20in%20vitro%2C%20but%20the%20protective%20effect%20in%20the%20neonatal%20period%20remains%20unknown.%20Herein%2C%20we%20evaluated%20the%20immunomodulatory%20and%20antiviral%20effects%20of%20IFN-I%20adjuvants%20on%20cord%20blood%20monocyte-derived%20macrophages%20upon%20HIV-1%20infection.%20Despite%20the%20phenotypic%20and%20transcriptional%20similarities%20between%20cord%20blood%20and%20adult%20macrophages%2C%20cord%20blood%20cells%20were%20prone%20to%20viral%20replication%20when%20infected%20with%20HIV-1.%20However%2C%20treatment%20with%20CL097%20efficiently%20promoted%20the%20antiviral%20and%20inflammatory%20responses%20and%20inhibited%20HIV-1%20replication%20in%20cord%20blood%20cells%20in%20an%20NF-%5Cu03baB%20and%20autophagy%20activation-independent%20manner.%20Our%20data%20suggest%20that%20cord%20blood%20macrophages%20are%20able%20to%20establish%20antiviral%20responses%20induced%20by%20IFN-I%20adjuvants%20similar%20to%20those%20of%20their%20adult%20counterparts%2C%20revealing%20a%20potential%20adjuvant%20candidate%20to%20enhance%20the%20neonatal%20immune%20response.%22%2C%22date%22%3A%22August%206%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Finfdis%5C%2Fjiab389%22%2C%22ISSN%22%3A%220022-1899%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Finfdis%5C%2Fjiab389%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-08-10T06%3A14%3A02Z%22%7D%7D%5D%7D
Pietrobon, A. J., Yoshikawa, F. S. Y., Oliveira, L. M., Pereira, N. Z., Matozo, T., de Alencar, B. C., Duarte, A. J. S., & Sato, M. N. (2021). Antiviral Response Induced by TLR7/TLR8 Activation Inhibits HIV-1 Infection in Cord Blood Macrophages. The Journal of Infectious Diseases, jiab389. https://doi.org/10.1093/infdis/jiab389 Cite