AKT

[Cancer Gene Therapy] The authors investigated the role nuclear receptors (NRs) played in colorectal cancer (CRC) pathogenesis. Overexpression of hepatocyte nuclear factor 4 gamma (HNF4G) significantly promoted the proliferation of CRC cells in vitro.

[Blood Advances] Dexamethasone and the myeloid cell leukemia 1 (MCL-1) inhibitor S63845 proved the most potent combination in a lethality screen and induced apoptosis of human myeloma cell lines that was 50% higher compared with an additive drug effect.

[Oral Diseases] Researchers investigated whether lysine-specific demethylase 1 (LSD1) affected the development of oral squamous cell carcinoma (OSCC) by sustaining the CSCs from OSCC.

[Signal Transduction and Targeted Therapy] Aberrant bone marrow-M1/M2 MФ polarization, characterized by increased M1 MФs and decreased M2 MФs and accompanied by impaired megakaryopoiesis-supporting abilities, was found in patients with thrombocytopenia post-allotransplant.

[Nature Immunology] Scientists found that upregulation of regulator of G protein signaling (RGS)1 in helper TH1 cells and cytotoxic T lymphocytes (CTLs) reduced their trafficking to and survival in tumors and was associated with shorter survival of patients with breast and lung cancer.

[Cells] Persistent cells were enriched for vimentinhigh sub-population, vimentin knockdown using siRNA approach decreased the invasive and sphere forming capacities as well as Akt phosphorylation in persistent cells, indicating that vimentin was involved in chemotherapeutic treatment-induced enhancement of TNBC aggressiveness.