Targeting Regulator of G Protein Signaling 1 in Tumor-Specific T Cells Enhances Their Trafficking to Breast Cancer

By
Justin.choi
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Scientists found that upregulation of regulator of G protein signaling (RGS)1 in helper TH1 cells and cytotoxic T lymphocytes (CTLs) reduced their trafficking to and survival in tumors and was associated with shorter survival of patients with breast and lung cancer.
[Nature Immunology]
Huang, D., Chen, X., Zeng, X., Lao, L., Li, J., Xing, Y., Lu, Y., Ouyang, Q., Chen, J., Yang, L., Su, F., Yao, H., Liu, Q., Su, S., & Song, E. (2021). Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer. Nature Immunology, 1–15. https://doi.org/10.1038/s41590-021-00939-9 Cite
Abstract