IL-23

[Scientific Reports] To alleviate the potential safety concerns, identifying compounds with skin-restricted exposure amenable for topical use was of great interest.

[Cell Reports] Investigators report that long-term stress surprisingly abrogates both T helper 1 (TH1)- and TH2-type responses orchestrated by invariant natural killer T cells.

[Scientific Reports] Researchers used an in vitro model of muscle cell ischemia in which primary human skeletal myoblasts were exposed to hypoxic conditions for 6 hours.

[Cell] Scientists targeted the shared IL-12Rβ1/p40 interface to design a panel of IL-12 partial agonists that preserved interferon gamma (IFNγ) induction by CD8 + T cells but impaired cytokine production from natural killer (NK) cells in vitro.

[International Journal of Molecular Sciences] The authors discuss the pathogenetic role of various cytokines in Hidradenitis suppurativa and potential therapeutic targets attempted or currently under investigation for this debilitating disease.

[Journal of Clinical Investigation] Scientists found that the expression of galectin-7 was reduced in the skin lesions of patients with psoriasis. IL-17A and TNF-α, two cytokines intimately involved in the development of psoriatic lesions, suppressed galectin-7 expression in human primary keratinocytes and the immortalized human keratinocyte cell line HaCaT.