Galectin-7 Downregulation in Lesional Keratinocytes Contributes to Enhanced IL-17A Signaling and Skin Pathology in Psoriasis

By
Justin.choi
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Scientists found that the expression of galectin-7 was reduced in the skin lesions of patients with psoriasis. IL-17A and TNF-α, two cytokines intimately involved in the development of psoriatic lesions, suppressed galectin-7 expression in human primary keratinocytes and the immortalized human keratinocyte cell line HaCaT.
[Journal of Clinical Investigation]
Chen, H.-L., Lo, C.-H., Huang, C.-C., Lu, M.-P., Hu, P.-Y., Chen, C.-S., Chueh, D.-Y., Chen, P., Lin, T.-N., Lo, Y.-H., Hsiao, Y.-P., Hsu, D. K., & Liu, F.-T. (2020). Galectin‐7 downregulation in lesional keratinocytes contributes to enhanced IL‐17A signaling and skin pathology in psoriasis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI130740 Cite
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