IL-6

[Scientific Reports] Scientists aimed to establish a new type of rapid liver hyperplasia model induced mainly by bile acid pathway through hepatoenteral circulation with hilar bile duct ligation. Immunohistochemistry results confirmed the proliferation of hepatocytes in the unligated liver lobe.

[Stem Cell Research & Therapy] The effect of MSCs on proliferation of anti-CD3/CD28-stimulated T CD4+ cells and generation of Tregs with or without pre-treatment with mitomycin C, IFN-γ and IL-1β was evaluated by flow cytometry.

[Journal of Cellular and Molecular Medicine] Researchers conducted a safety and efficacy study that included ten patients with a median age of 50 years with COVID-19-induced acute respiratory distress syndrome (ARDS).

[Inflammatory Bowel Diseases] Researchers investigated if selective blocking of neuropeptide Y (NPY) receptors, NPY1R or NPY2R, using small molecule non-peptide antagonists (BIBP-3222 for NPY1R and BIIE-0246 for NPY2R) in the colon could attenuate intestinal inflammation by lowering TNF levels.

[Scientific Reports] To explore the relationship between PLCγ2 and TREM2 and the role of PLCγ2 in regulating immune cell function, the authors generated human iPSC- derived macrophages from isogenic lines with homozygous PLCG2 knockout.

[Stem Cells and Development] Investigators found that TNF-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.