chronic kidney disease

[Journal of Clinical Investigation] SIRT6-transgenic mice showed alleviated vascular calcification (VC), while vascular smooth muscle cells-specific, SIRT6 knocked down mice showed severe VC, in chronic kidney disease.

[American Journal of Nephrology] Investigators summarize the roles of the kynurenine pathway and its metabolites in acute kidney injury and chronic kidney disease based on current literature evidence.

[Scientific Reports] Investigators reported a role for excessive neutrophil extracellular trap formation induced by uremic serum on endothelial cell injury.

[Cell Death Discovery] The authors indicated that RCAN1.4 expression was impaired both in unilateral ureteral obstruction-induced renal fibrosis in vivo and TGF-β1-induced renal fibrosis in vitro. However, knocking in of RCAN1.4 suppressed the production of ECM both in vivo and in vitro.

[Biomedicine & Pharmacotherapy] Scientists determined whether serelaxin (RLX) could enhance the therapeutic efficacy of bone-marrow-derived- mesecnymal stem cell-exosomes (BM-MSC-EXO), and compared the renoprotective effects of RLX and BM-MSC-EXO versus RLX and BM-MSCs in mice with hypertensive CKD.

[Pflugers Archiv-European Journal of Physiology] Scientists explored the effects of β2-adrenergic stimulation by isoproterenol on vascular smooth muscle cells (VSMC) calcification. Experiments were performed in primary human aortic VSMCs treated with isoproterenol during control or high phosphate conditions.