cyclin D1

[Oncoimmunology] Researchers investigated the effects of CDK4/6i, abemaciclib and palbociclib, on the immunopeptidome at nontoxic levels in breast cancer cell lines using biochemical identification of HLA ligands followed by network analyses.

[Oncogenesis] The authors showed YWHAE-NUTM2 complexes with both BRAF/RAF1 and YAP/TAZ in high-grade endometrial stromal sarcoma (HG-ESS). These interactions were functionally relevant because YWHAE-NUTM2 knockdown in HG-ESS and other models inhibits RAF/MEK/MAPK phosphorylation, cyclin D1 expression, and cell proliferation.

[Amb Express] The authors elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells and compared them with commercial drug cisplatin.

[Cell Death & Disease] Investigators explored the novel mechanisms by which exosome-contained circRNAs promoted tumor development and metastasis in TNBC.

[Scientific Reports] Researchers showed that genetic or pharmacological inhibition of eukaryotic elongation factor-2 kinase (eEF2K) cooperated with glutamine starvation, and synergized with glutaminase inhibitors to suppress growth of diverse TNBC cell lines.

[Experimental Cell Research] Researchers show CREB phosphorylation was required for smooth muscle cell proliferation in response to platelet-derived growth factor (PDGF). This phenotypic change required CBP and was mediated by Cyclin D1 and p27kip as a result of changes in FoxO1 activity.