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Pulmonary Cell NewsThe authors showed YWHAE-NUTM2 complexes with both BRAF/RAF1 and YAP/TAZ in high-grade endometrial stromal sarcoma (HG-ESS). These interactions were functionally relevant because YWHAE-NUTM2 knockdown in HG-ESS and other models inhibits RAF/MEK/MAPK phosphorylation, cyclin D1 expression, and cell proliferation.
[Oncogenesis]
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Ou, W.-B., Lundberg, M. Z., Zhu, S., Bahri, N., Kyriazoglou, A., Xu, L., Chen, T., Mariño-Enriquez, A., & Fletcher, J. A. (2021). YWHAE-NUTM2 oncoprotein regulates proliferation and cyclin D1 via RAF/MAPK and Hippo pathways. Oncogenesis, 10(5), 1–9. https://doi.org/10.1038/s41389-021-00327-w Cite
