eosinophils

[European Respiratory Journal] Researchers summarize the current understanding of the biology of type 2 inflammation in asthma, examine its influence on type 2 inflammatory comorbidities, and discuss how type 2 inflammatory biomarkers can be harnessed to further personalise treatments in the age of biologic medicines.

[Journal of Internal Medicine] The authors compare genetics, microbiome, T‐cell infiltrate and resulting epithelial response in psoriasis and atopic dermatitis.

[Nature Communications] Mechanistic studies revealed roles of eosinophil IL4 and cationic protein mEar1 in blocking H2O2- and hypoxia-induced mouse and human cardiomyocyte death, TGF-β-induced cardiac fibroblast Smad2/3 activation, and TNF-α-induced neutrophil adhesion on the heart endothelial cell monolayer.

[Experimental Physiology] Investigators examined the effects of human amniotic membrane MSCs‐conditioned medium on ovalbumin (OVA)‐induced asthma. 48 hours after the last challenge, serum and bronchoalveolar lavage fluid samples were collected and used for evaluation of inflammatory factors and cells, respectively.

[European Respiratory Journal] Blood eosinophils were increased in surviving patients with acute respiratory distress syndrome (ARDS) independent of corticosteroid usage. There existed homeostatic eosinophils in lung parenchyma in mice and these homeostatic eosinophils, originating from the bone marrow, were predominantly CD101−.

[Aging] Investigators combined immune landscape signatures with hepatocellular carcinoma clinical and prognostic features to classify them into distinct subtypes. The immunogenomic profiles, stromal cell features and immune cell composition of the subtypes were then systematically analyzed.