Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsResearchers summarize the current understanding of the biology of type 2 inflammation in asthma, examine its influence on type 2 inflammatory comorbidities, and discuss how type 2 inflammatory biomarkers can be harnessed to further personalise treatments in the age of biologic medicines.
[European Respiratory Journal]
1254621 {1254621:DT3LUZZL} apa 50 1 158799 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-63c0e9ecccf27271ec85fb317d9bad85%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22DT3LUZZL%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Busse%20et%20al.%22%2C%22parsedDate%22%3A%222021-01-01%22%2C%22numChildren%22%3A3%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EBusse%2C%20W.%20W.%2C%20Kraft%2C%20M.%2C%20Rabe%2C%20K.%20F.%2C%20Deniz%2C%20Y.%2C%20Rowe%2C%20P.%2C%20Ruddy%2C%20M.%2C%20%26amp%3B%20Castro%2C%20M.%20%282021%29.%20Understanding%20the%20key%20issues%20in%20the%20treatment%20of%20uncontrolled%20persistent%20asthma%20with%20type%202%20inflammation.%20%3Ci%3EEuropean%20Respiratory%20Journal%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.03393-2020%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1183%5C%2F13993003.03393-2020%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D1254621%26amp%3Bitem_key%3DDT3LUZZL%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Understanding%20the%20key%20issues%20in%20the%20treatment%20of%20uncontrolled%20persistent%20asthma%20with%20type%202%20inflammation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20W.%22%2C%22lastName%22%3A%22Busse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monica%22%2C%22lastName%22%3A%22Kraft%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%20F.%22%2C%22lastName%22%3A%22Rabe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yamo%22%2C%22lastName%22%3A%22Deniz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Rowe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcella%22%2C%22lastName%22%3A%22Ruddy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mario%22%2C%22lastName%22%3A%22Castro%22%7D%5D%2C%22abstractNote%22%3A%22Asthma%20is%20a%20complex%20respiratory%20disease%20that%20varies%20in%20severity%20and%20response%20to%20treatment.%20Several%20asthma%20phenotypes%20with%20unique%20clinical%20and%20inflammatory%20characteristics%20have%20been%20identified.%20Endotypes%2C%20based%20on%20distinct%20molecular%20profiles%2C%20help%20to%20further%20understand%20the%20heterogeneity%20within%20asthma.%20Type%202%20inflammation%2C%20involving%20both%20the%20innate%20%28type%202%20innate%20lymphoid%20cell%29%20and%20adaptive%20%28T%20helper%20type%202%20cells%29%20immune%20systems%2C%20underpins%20the%20complex%20pathophysiology%20of%20chronic%20inflammation%20in%20asthma%2C%20as%20well%20as%20the%20presence%20of%20comorbid%20disease%20%28such%20as%20chronic%20rhinosinusitis%20with%20nasal%20polyps%2C%20allergic%20rhinitis%2C%20and%20atopic%20dermatitis%29.%20Type%202%20inflammation%20is%20characterised%20by%20upregulation%20of%20type%202%20cytokines%20interleukin%20%28IL%29-4%2C%20IL-5%2C%20and%20IL-13%2C%20immunoglobulin%20E%20%28IgE%29-mediated%20release%20of%20immune%20mediators%2C%20and%20dysfunction%20of%20epithelial%20or%20epidermal%20barriers.%20Targeting%20these%20key%20proximal%20type%202%20cytokines%20has%20shown%20efficacy%20in%20recent%20studies%20adopting%20a%20personalised%20approach%20to%20treatment%20using%20targeted%20biologics.%20Elevated%20levels%20of%20biomarkers%20downstream%20of%20type%202%20cytokines%2C%20including%20fractional%20exhaled%20nitric%20oxide%2C%20serum%20IgE%2C%20and%20blood%20and%20sputum%20eosinophils%2C%20have%20been%20linked%20to%20mechanisms%20involved%20in%20type%202%20inflammation%2C%20and%20have%20the%20potential%20to%20aid%20diagnosis%2C%20and%20predict%20and%20monitor%20response%20to%20treatment.%20The%20objective%20of%20this%20review%20is%20to%20summarise%20the%20current%20understanding%20of%20the%20biology%20of%20type%202%20inflammation%20in%20asthma%2C%20examine%20its%20influence%20on%20type%202%20inflammatory%20comorbidities%2C%20and%20discuss%20how%20type%202%20inflammatory%20biomarkers%20can%20be%20harnessed%20to%20further%20personalise%20treatments%20in%20the%20age%20of%20biologic%20medicines.%22%2C%22date%22%3A%222021%5C%2F01%5C%2F01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1183%5C%2F13993003.03393-2020%22%2C%22ISSN%22%3A%220903-1936%2C%201399-3003%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Ferj.ersjournals.com%5C%2Fcontent%5C%2Fearly%5C%2F2021%5C%2F01%5C%2F08%5C%2F13993003.03393-2020%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-02-05T19%3A02%3A34Z%22%7D%7D%5D%7D
Busse, W. W., Kraft, M., Rabe, K. F., Deniz, Y., Rowe, P., Ruddy, M., & Castro, M. (2021). Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation. European Respiratory Journal. https://doi.org/10.1183/13993003.03393-2020 Cite
