intestinal epithelial cells

[Nature Cell Biology] Prostaglandin E2 signaling via the E-type prostanoid receptor 4 (EP4) on intestinal epithelial cells repressed epithelial necroptosis and induced resolution of colitis. EP4 expression correlated with an improved IBD outcome and EP4 activation induced a transcriptional signature consistent with resolution of intestinal inflammation.

[Scientific Reports] Scientists demonstrated that membrane vesicles from Lacticaseibacillus rhamnosus JB-1 were endocytosed in a likely clathrin-dependent manner by both mouse and human intestinal epithelial cells (IECs) in vitro and by mouse IEC in vivo.

[Trends in Immunology] Scientists discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells (intestinal epithelial cells and type-3 innate lymphoid cells) determine how the intestinal barrier and host–microbiota–pathogens connections are molded.

[Cell Reports] Researchers generated intestinal epithelial cell (IEC)-specific RNA helicase DEAH-box helicase 15 (DHX15)-knockout mice and demonstrated that DHX15 was required for controlling intestinal inflammation. Mechanistically, DHX15 interacted with NLRP6 to trigger NLRP6 inflammasome assembly and activation for inducing IL-18 secretion in IECs.

[Analytical Chemistry] Scientists developed an impedance system to measure the change in electrical resistance of 3D HIOs depending on the integrity of the intestinal epithelial cell membrane, which can reflect functionality and maturity.

[Cell Death & Disease] Neutrophil extracellular traps treatment induced intestinal epithelial monolayer barrier disruption and endoplasmic reticulum (ER) stress activation in a dose-dependent manner in vitro, and ER stress inhibition markedly attenuated intestinal apoptosis and tight junction injury.