Tag results:
macrophages
Immunology of Infectious Disease News
Monocyte Metabolic Transcriptional Programs Associate with Resistance to Tuberculin Skin Test/Interferon-γ Release Assay Conversion
[Journal of Clinical Investigation] To identify mechanisms of resistance to Mycobacterium tuberculosis (Mtb) infection, scientists compared transcriptional profiles from highly-exposed contacts who resist tuberculin skin test/interferon-γ release assay conversion and controls with latent Mtb infection using RNAseq.
Pulmonary Cell News
Metformin Inhibition of Mitochondrial ATP and DNA Synthesis Abrogates NLRP3 Inflammasome Activation and Pulmonary Inflammation
[Immunity] Researchers showed that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide- and SARS-CoV-2-induced Acute respiratory distress syndrome.
Organoid News
D-Dopachrome Tautomerase Contributes to Lung Epithelial Repair via Atypical Chemokine Receptor 3-Dependent Akt Signaling
[Ebiomedicine] Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.
Immune Regulation News
Alternative Activation of Macrophages by Prostacyclin Synthase Ameliorates Alcohol Induced Liver Injury
[Laboratory Investigation] Investigators demonstrated that PTGIS was downregulated in alchoholic liver disease and forced PTGIS expression in vivo using recombinant adeno-associated viral vector-packed prostacyclin synthase overexpression plasmid, which alleviated the inflammatory response and suppressed the macrophage M1 phenotype in mice.
Immune Regulation News
Targeting Monoamine Oxidase A-Regulated Tumor-Associated Macrophage Polarization for Cancer Immunotherapy
[Nature Communications] Scientists observed monoamine oxidase A (MAO-A) induction in mouse and human tumor-associated macrophages (tAMs). MAO-A-deficient mice exhibit decreased TAM immunosuppressive functions corresponding with enhanced antitumor immunity.
Human Immunology News
Characteristics and Spatially-Defined Immune (Micro)landscapes of Early-Stage PD-L1-Positive Triple-Negative Breast Cancer
[Clinical Cancer Research] A large cohort of chemotherapy-naïve triple-negative breast cancer (TNBC), clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME were identified in subsets of PD-L1+ and PD-L1- TNBC.