organoids

[Nature Communications] Researchers showed that active mechanical forces increase growth and lead to enhanced patterning in an organoid model of the neural tube derived from single human pluripotent stem cells (hPSC).

[Archives of Toxicology] Differentiation of organoids significantly increased the expression of multiple cytochrome P450, phase II enzymes, liver biomarkers and hepatic transporters. The differentiated organoids were shown to exhibit increased sensitivity to midazolam and irinotecan, when compared to the undifferentiated organoids.

[iScience] Scientists reported that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analogue, Nortopsentin 234, led to an initial reduction of proliferative and clonogenic potential of colorectal cancer sphere cells (CR-CSphCs), followed by an adaptive response selecting the CR-CSphCs resistant compartment.

[Proceedings of the National Academy of Sciences of the United States of America] Using intestinal organoids, researchers showed that concomitant activation of Notch signaling and ablation of p53 induce a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.

[Nature Communications] The authors showed that active mechanical forces increase growth and led to enhanced patterning in an organoid model of the neural tube derived from single human pluripotent stem cells.

[EMBO Reports] Scientists found increased COUP-TFII expression in myofibroblasts in human fibrotic kidneys, lungs, kidney organoids, and mouse kidneys after injury.