osteoclasts

[Nature Reviews Clinical Oncology] The authors describe the functional roles of the bone microenvironment and its components in the initiation and propagation of skeletal metastases, outline the biology and clinical relevance of circulating tumor cells and disseminated tumor cells, and discuss established and future therapeutic approaches that specifically target defined components of the bone microenvironment to prevent or treat skeletal metastases.

[Cell Death & Disease] Scientists proposed a novel mechanism for transcription factor EB (TFEB) governing pluripotency of mESCs by regulating the pluripotency transcriptional network.

[Experimental and Molecular Medicine] Inhibition of senescence-induced upregulation of hypoxia-inducible factor-2α expression during matrix maturation, but not during the proliferation stage of osteoblast differentiation, reversed the age-related decrease in Runx2 and Ocn expression.

[Bone & Joint Research] Investigators uncovered the hub long non-coding RNAs differentially expressed in osteoarthritis cartilage using an integrated analysis of the competing endogenous RNA network and co-expression network.

[American Journal of Respiratory Cell and Molecular Biology] The effect of cigarette smoke extract on RANKL/RANK expression and that of exogenous RANKL on ubiquitin-proteasome pathway in C2C12 myotubes were investigated in vitro.

[Bone Research] Investigators discuss that the Pyk2-mediated actin polymerization pathway in osteoclasts and microglia in bone and brain, respectively, is the horizontal pleiotropic mediator of shared risk factors for osteoporosis and Alzheimer’s disease.