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Pulmonary Cell NewsThe authors investigated the effects of tyrosine kinase inhibitors (TKIs) on the development of endothelial-to-mesenchymal transition in human vascular-endothelial cells (VECs). Exposure of VECs to dasatinib, but not to other TKIs, produced a significant increase in the formation of spindle-shaped cells.
[International Journal of Hematology]
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Alkebsi, L., Wang, X., Ohkawara, H., Fukatsu, M., Mori, H., & Ikezoe, T. (2021). Dasatinib induces endothelial-to-mesenchymal transition in human vascular-endothelial cells: counteracted by cotreatment with bosutinib. International Journal of Hematology. https://doi.org/10.1007/s12185-020-03034-1 Cite
