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Pulmonary Cell NewsInvestigators developed a simple culture protocol under which the adult murine inguinal adipose tissue-derived stromal vascular fraction (Ad-SVF) reproducibly transdifferentiates into beating cardiomyocyte (CMs) without induction. The beating CMs showed the striated ventricular phenotype of cardiomyocytes and synchronised oscillation of the intracellular calcium concentration among cells on day 28 of Ad-SVF primary culture.
[Scientific Reports]
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Takashima, S., Usui, S., Inoue, O., Goten, C., Yamaguchi, K., Takeda, Y., Cui, S., Sakai, Y., Hayashi, K., Sakata, K., Kawashiri, M., & Takamura, M. (2021). Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells. Scientific Reports, 11(1), 1520. https://doi.org/10.1038/s41598-020-80848-3 Cite
