By using mouse genetics, lineage tracing, and organoid culture, scientists examined the development of the squamous–columnar junction in the mouse stomach, and thus define the unique features of transitional epithelium.
[Nature Communications]
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Sankoda, N., Tanabe, W., Tanaka, A., Shibata, H., Woltjen, K., Chiba, T., Haga, H., Sakai, Y., Mandai, M., Yamamoto, T., Yamada, Y., Uemoto, S., & Kawaguchi, Y. (2021). Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice. Nature Communications, 12(1), 560. https://doi.org/10.1038/s41467-021-20906-0 Cite