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Pulmonary Cell NewsScientists obtained γδ and αβ TCR sequences of >2500 single cells from blood and gut of 5 patients, before and during challenge. We observed extensive sharing between blood and gut γδ and CD8+ αβ T-cell clonotypes even prior to gluten challenge.
[Mucosal Immunology]
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Risnes, L. F., Eggesbø, L. M., Zühlke, S., Dahal-Koirala, S., Neumann, R. S., Lundin, K. E. A., Christophersen, A., & Sollid, L. M. (2021). Circulating CD103 + γδ and CD8 + T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease. Mucosal Immunology, 1–10. https://doi.org/10.1038/s41385-021-00385-8 Cite
