Transforming growth factor-beta (TGF-β), by internalization of the epithelial sodium channel (ENaC), suppresses the anti-oxidant system, downregulates the cystic fibrosis transmembrane conductance regulator (CFTR), and activates the plasminogen activator inhibitor 1 (PAI-1) and nuclear factor-kappa-light-chain-enhancer of activated B cells (NF-kB).
[Pharmacological Reports]
7753456 {7753456:9SVENKXU} apa 50 1 161713 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/ %7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-4e917f3f1359826566baf10d0af14c64%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229SVENKXU%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hamidi%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-21%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EHamidi%2C%20S.%20H.%2C%20Kadamboor%20Veethil%2C%20S.%2C%20%26amp%3B%20Hamidi%2C%20S.%20H.%20%282021%29.%20Role%20of%20pirfenidone%20in%20TGF-%26%23x3B2%3B%20pathways%20and%20other%20inflammatory%20pathways%20in%20acute%20respiratory%20syndrome%20coronavirus%202%20%28SARS-Cov-2%29%20infection%3A%20a%20theoretical%20perspective.%20%3Ci%3EPharmacological%20Reports%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs43440-021-00255-x%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs43440-021-00255-x%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D9SVENKXU%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Role%20of%20pirfenidone%20in%20TGF-%5Cu03b2%20pathways%20and%20other%20inflammatory%20pathways%20in%20acute%20respiratory%20syndrome%20coronavirus%202%20%28SARS-Cov-2%29%20infection%3A%20a%20theoretical%20perspective%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seyed%20Hootan%22%2C%22lastName%22%3A%22Hamidi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandhya%22%2C%22lastName%22%3A%22Kadamboor%20Veethil%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Seyedeh%20Harir%22%2C%22lastName%22%3A%22Hamidi%22%7D%5D%2C%22abstractNote%22%3A%22Severe%20acute%20respiratory%20syndrome%20coronavirus%202%20%28SARS-CoV-2%29%20causes%20pulmonary%20injury%20or%20multiple-organ%20injury%20by%20various%20pathological%20pathways.%20Transforming%20growth%20factor-beta%20%28TGF-%5Cu03b2%29%20is%20a%20key%20factor%20that%20is%20released%20during%20SARS-CoV-2%20infection.%20TGF-%5Cu03b2%2C%20by%20internalization%20of%20the%20epithelial%20sodium%20channel%20%28ENaC%29%2C%20suppresses%20the%20anti-oxidant%20system%2C%20downregulates%20the%20cystic%20fibrosis%20transmembrane%20conductance%20regulator%20%28CFTR%29%2C%20and%20activates%20the%20plasminogen%20activator%20inhibitor%201%20%28PAI-1%29%20and%20nuclear%20factor-kappa-light-chain-enhancer%20of%20activated%20B%20cells%20%28NF-kB%29.%20These%20changes%20cause%20inflammation%20and%20lung%20injury%20along%20with%20coagulopathy.%20Moreover%2C%20reactive%20oxygen%20species%20play%20a%20significant%20role%20in%20lung%20injury%2C%20which%20levels%20up%20during%20SARS-CoV-2%20infection.%22%2C%22date%22%3A%222021-04-21%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs43440-021-00255-x%22%2C%22ISSN%22%3A%222299-5684%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs43440-021-00255-x%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%2243ZBJFKZ%22%5D%2C%22dateModified%22%3A%222021-04-21T21%3A50%3A33Z%22%7D%7D%5D%7DHamidi, S. H., Kadamboor Veethil, S., & Hamidi, S. H. (2021). Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical perspective.
Pharmacological Reports.
https://doi.org/10.1007/s43440-021-00255-x Cite 
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