Investigators showed that the CD200-CD200R pathway restrained activation of CD200R+ lesional macrophages, their production of CCR2 ligands, and monocyte recruitment in vitro and in vivo in an air pouch model.
[Circulation Research]
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Kassiteridi Christina, Cole Jennifer E, Griseri Thibault, Falck-Hansen Mika, Goddard Michael E, Seneviratne Anusha N, Green Patricia Ann, Park Inhye, Shami Annelie, Pattarabanjird Tanyaporn, Upadhye Aditi, Taylor Angela M, Handa Ashok, Channon Keith M, Lutgens Esther, McNamara Coleen A, Williams Richard O, & Monaco Claudia. (n.d.). CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316062 Cite