Activity of Immunoproteasome Inhibitor ONX-0914 in Acute Lymphoblastic Leukemia Expressing MLL–AF4 Fusion Protein

Researchers found that acute lymphoblastic leukemia cells expressing MLL–AF4 fusion protein expressed high levels of lymphoid tissue-specific immunoproteasomes and were sensitive to pharmacologically relevant concentrations of specific immunoproteasome inhibitor ONX-0914.