When combined with dabrafenib and/or trametinib, Melaleuca alternifolia synergistically reduced the viability of melanoma cells by activating apoptosis.
[Cell Death Discovery]
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Di Martile, M., Garzoli, S., Sabatino, M., Valentini, E., D’Aguanno, S., Ragno, R., & Del Bufalo, D. (2021). Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models. Cell Death Discovery, 7(1), 1–13. https://doi.org/10.1038/s41420-021-00510-3 Cite