Researchers showed that restricted chromatin accessibility in intestinal stem cells prevented the expression of β-Catenin-regulated metabolic enzymes, whereas fine-tuning of WNT/β-Catenin activity by ZNRF3 and RNF43 restricted proliferation in chromatin-permissive AXIN2+ hepatocytes, while preserving metabolic function.
[Cell Stem Cell]
7753456
{7753456:JXKWFHGC}
apa
50
1
163590
https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-b73554f3f4ca9d11c911d9412794f970%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22JXKWFHGC%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Sun%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-14%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESun%2C%20T.%2C%20Annunziato%2C%20S.%2C%20Bergling%2C%20S.%2C%20Sheng%2C%20C.%2C%20Orsini%2C%20V.%2C%20Forcella%2C%20P.%2C%20Pikiolek%2C%20M.%2C%20Kancherla%2C%20V.%2C%20Holwerda%2C%20S.%2C%20Imanci%2C%20D.%2C%20Wu%2C%20F.%2C%20Meylan%2C%20L.%20C.%2C%20Puehringer%2C%20L.%20F.%2C%20Waldt%2C%20A.%2C%20Oertli%2C%20M.%2C%20Schuierer%2C%20S.%2C%20Terracciano%2C%20L.%20M.%2C%20Reinker%2C%20S.%2C%20Ruffner%2C%20H.%2C%20%26%23x2026%3B%20Tchorz%2C%20J.%20S.%20%282021%29.%20ZNRF3%20and%20RNF43%20cooperate%20to%20safeguard%20metabolic%20liver%20zonation%20and%20hepatocyte%20proliferation.%20%3Ci%3ECell%20Stem%20Cell%3C%5C%2Fi%3E%2C%20%3Ci%3E0%3C%5C%2Fi%3E%280%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.stem.2021.05.013%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.stem.2021.05.013%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DJXKWFHGC%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22ZNRF3%20and%20RNF43%20cooperate%20to%20safeguard%20metabolic%20liver%20zonation%20and%20hepatocyte%20proliferation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tianliang%22%2C%22lastName%22%3A%22Sun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Annunziato%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Bergling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caibin%22%2C%22lastName%22%3A%22Sheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Orsini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pascal%22%2C%22lastName%22%3A%22Forcella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monika%22%2C%22lastName%22%3A%22Pikiolek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Venkatesh%22%2C%22lastName%22%3A%22Kancherla%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sjoerd%22%2C%22lastName%22%3A%22Holwerda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dilek%22%2C%22lastName%22%3A%22Imanci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabian%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ludivine%20Challet%22%2C%22lastName%22%3A%22Meylan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lea%20F.%22%2C%22lastName%22%3A%22Puehringer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annick%22%2C%22lastName%22%3A%22Waldt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mevion%22%2C%22lastName%22%3A%22Oertli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sven%22%2C%22lastName%22%3A%22Schuierer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Luigi%20M.%22%2C%22lastName%22%3A%22Terracciano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Reinker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Heinz%22%2C%22lastName%22%3A%22Ruffner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tewis%22%2C%22lastName%22%3A%22Bouwmeester%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20W.%22%2C%22lastName%22%3A%22Sailer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elizabeth%22%2C%22lastName%22%3A%22George%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Guglielmo%22%2C%22lastName%22%3A%22Roma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%20de%22%2C%22lastName%22%3A%22Weck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salvatore%22%2C%22lastName%22%3A%22Piscuoglio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felix%22%2C%22lastName%22%3A%22Lohmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%22%2C%22lastName%22%3A%22Naumann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Prisca%22%2C%22lastName%22%3A%22Liberali%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Cong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20S.%22%2C%22lastName%22%3A%22Tchorz%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222021-06-14%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.stem.2021.05.013%22%2C%22ISSN%22%3A%221934-5909%2C%201875-9777%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.cell.com%5C%2Fcell-stem-cell%5C%2Fabstract%5C%2FS1934-5909%2821%2900250-2%22%2C%22collections%22%3A%5B%22NTMX856R%22%5D%2C%22dateModified%22%3A%222021-06-14T17%3A24%3A20Z%22%7D%7D%5D%7D
Sun, T., Annunziato, S., Bergling, S., Sheng, C., Orsini, V., Forcella, P., Pikiolek, M., Kancherla, V., Holwerda, S., Imanci, D., Wu, F., Meylan, L. C., Puehringer, L. F., Waldt, A., Oertli, M., Schuierer, S., Terracciano, L. M., Reinker, S., Ruffner, H., … Tchorz, J. S. (2021). ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.05.013 Cite
