Scientists demonstrated that PTT-induced in situ vaccination cancer therapy can elicit potent antitumor immunity against disseminated and metastatic tumors.
[Biomaterials]
6445212 7EKS4X57 items 1 apa 0 default asc 1 163609 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-5cebbb7f44cad5f40a61ea61685cf2e5%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%227EKS4X57%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Liu%20et%20al.%22%2C%22parsedDate%22%3A%222021-08-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELiu%2C%20X.%2C%20Su%2C%20Q.%2C%20Song%2C%20H.%2C%20Shi%2C%20X.%2C%20Zhang%2C%20Y.%2C%20Zhang%2C%20C.%2C%20Huang%2C%20P.%2C%20Dong%2C%20A.%2C%20Kong%2C%20D.%2C%20%26amp%3B%20Wang%2C%20W.%20%282021%29.%20PolyTLR7%5C%2F8a-conjugated%2C%20antigen-trapping%20gold%20nanorods%20elicit%20anticancer%20immunity%20against%20abscopal%20tumors%20by%20photothermal%20therapy-induced%20in%20situ%20vaccination.%20%3Ci%3EBiomaterials%3C%5C%2Fi%3E%2C%20%3Ci%3E275%3C%5C%2Fi%3E%2C%20120921.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biomaterials.2021.120921%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.biomaterials.2021.120921%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D7EKS4X57%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22PolyTLR7%5C%2F8a-conjugated%2C%20antigen-trapping%20gold%20nanorods%20elicit%20anticancer%20immunity%20against%20abscopal%20tumors%20by%20photothermal%20therapy-induced%20in%20situ%20vaccination%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiang%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qi%22%2C%22lastName%22%3A%22Su%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huijuan%22%2C%22lastName%22%3A%22Song%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoguang%22%2C%22lastName%22%3A%22Shi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuming%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chuangnian%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pingsheng%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anjie%22%2C%22lastName%22%3A%22Dong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Deling%22%2C%22lastName%22%3A%22Kong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Weiwei%22%2C%22lastName%22%3A%22Wang%22%7D%5D%2C%22abstractNote%22%3A%22Nanovaccine%20can%20elicit%20antigen-specific%20immune%20responses%20against%20tumor%20cells%20expressing%20homologous%20antigens%20and%20has%20attracted%20enormous%20attention%20in%20cancer%20immunotherapy.%20However%2C%20tumor%20heterogeneity%20remarkably%20hinders%20the%20development%20of%20nanovaccines.%20Here%20we%20demonstrate%20that%20PTT-induced%20in%20situ%20vaccination%20cancer%20therapy%20can%20elicit%20potent%20antitumor%20immunity%20against%20disseminated%20and%20metastatic%20tumors.%20Gold%20nanorods%20%28AuNRs%29%20covalently%20coupled%20with%20amphiphilic%20polyTLR7%5C%2F8a%20and%20MMP-2-sensitive%20R9-PEG%20conjugate%20%28AuNRs-IMQD-R9-PEG%29%20were%20developed%20as%20a%20new%20biocompatible%20PTT%20agent%20with%20favorable%20photothermal%20efficiency%20and%20stability.%20Importantly%2C%20AuNRs-IMQD-R9-PEG%20can%20effectively%20absorb%20tumor-derived%20protein%20antigens%2C%20forming%20nanovaccines%20directly%20in%20vivo%20and%20enhance%20the%20activation%20of%20host%20dendritic%20cells%20%28DCs%29%2C%20thereby%20amplifying%20adaptive%20antitumor%20T-cell%20responses%2C%20triggering%20effector%20memory%20immune%20responses%2C%20and%20activating%20innate%20antitumor%20immunity.%20Remarkably%2C%20peri-tumoral%20administration%20of%20low-dose%20multifunctional%20AuNRs%20followed%20by%20non-invasive%20near-infrared%20%28NIR%29%20laser%20irradiation%20enables%20efficient%20tandem%20PTT-vaccination%20treatment%20modality%20that%20can%20inhibit%20local%20as%20well%20as%20untreated%20distant%20and%20metastatic%20tumors%20in%20mice%20inoculated%20with%20poorly%20immunogenic%2C%20highly%20metastatic%204T1%20tumors.%20Our%20findings%20indicate%20that%20AuNRs-IMQD-R9-PEG-mediated%20in%20situ%20cancer%20vaccination%20provides%20a%20powerful%20immunotherapy%20characterized%20by%20markedly%20increased%20infiltration%20of%20effector%20CD8%2B%20T%2C%20natural%20killer%20T%20%28NKT%29%20cells%20in%20tumors%20and%20long-term%20animal%20survival%2C%20thus%2C%20offering%20a%20promising%20therapeutic%20strategy%20for%20advanced%2C%20disseminated%20cancers.%22%2C%22date%22%3A%22August%201%2C%202021%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.biomaterials.2021.120921%22%2C%22ISSN%22%3A%220142-9612%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.sciencedirect.com%5C%2Fscience%5C%2Farticle%5C%2Fpii%5C%2FS0142961221002775%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-18T16%3A19%3A29Z%22%7D%7D%5D%7D
Liu, X., Su, Q., Song, H., Shi, X., Zhang, Y., Zhang, C., Huang, P., Dong, A., Kong, D., & Wang, W. (2021). PolyTLR7/8a-conjugated, antigen-trapping gold nanorods elicit anticancer immunity against abscopal tumors by photothermal therapy-induced in situ vaccination. Biomaterials, 275, 120921. https://doi.org/10.1016/j.biomaterials.2021.120921 Cite