To identify predictors of clinical benefit to immune checkpoint blockade, investigators performed immunogenomic profiling of tumor samples from patients with relapsed small cell lung cancer.
[Nature Communications]
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Roper, N., Velez, M. J., Chiappori, A., Kim, Y. S., Wei, J. S., Sindiri, S., Takahashi, N., Mulford, D., Kumar, S., Ylaya, K., Trindade, C., Manukyan, I., Brown, A.-L., Trepel, J. B., Lee, J.-M., Hewitt, S., Khan, J., & Thomas, A. (2021). Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer. Nature Communications, 12(1), 3880. https://doi.org/10.1038/s41467-021-24164-y Cite