Characterization of GECPAR, a Noncoding RNA That Regulates the Transcriptional Program of Diffuse Large B Cell Lymphoma

Using diffuse large B cell lymphoma cell line models, the authors demonstrated the tumor suppressor activity of Germinal Center Proliferative Adapter RNA (GECPAR), which was mediated via its transcriptional regulation of proliferation and differentiation genes, particularly MYC and the Wnt pathways.