Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsIntravenously treating with single strain for three times, or with both strains alternately for three times significantly reduced the tumor size and prolonged the survival time of model mice.
[Scientific Reports]
6445212 7JQL9IK4 items 1 apa 0 default asc 1 163999 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-d57b11dddf62990fae9a055e13ecf0b8%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%227JQL9IK4%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Su%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-28%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ESu%2C%20L.%2C%20Zhang%2C%20Y.%2C%20Zhang%2C%20X.%2C%20Liu%2C%20T.%2C%20Liu%2C%20S.%2C%20Li%2C%20Y.%2C%20Jiang%2C%20M.%2C%20Tang%2C%20T.%2C%20Shen%2C%20H.%2C%20%26amp%3B%20Wang%2C%20C.%20%282021%29.%20Combination%20immunotherapy%20with%20two%20attenuated%20Listeria%20strains%20carrying%20shuffled%20HPV-16%20E6E7%20protein%20causes%20tumor%20regression%20in%20a%20mouse%20tumor%20model.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2013404.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-92875-9%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-92875-9%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D7JQL9IK4%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Combination%20immunotherapy%20with%20two%20attenuated%20Listeria%20strains%20carrying%20shuffled%20HPV-16%20E6E7%20protein%20causes%20tumor%20regression%20in%20a%20mouse%20tumor%20model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lin%22%2C%22lastName%22%3A%22Su%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yunwen%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiang%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ting%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sijing%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yongyu%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mingjuan%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tian%22%2C%22lastName%22%3A%22Tang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Haiqian%22%2C%22lastName%22%3A%22Shen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chuan%22%2C%22lastName%22%3A%22Wang%22%7D%5D%2C%22abstractNote%22%3A%22Cervical%20cancer%20continues%20to%20impose%20a%20heavy%20burden%20worldwide%2C%20and%20human%20papilloma%20virus%20%28HPV%29%20infection%2C%20especially%20persistent%20infection%20with%20type%2016%20%28HPV-16%29%2C%20is%20known%20to%20be%20the%20primary%20etiological%20factor.%20Therapeutic%20vaccines%20are%20urgently%20needed%20because%20prophylactic%20vaccines%20are%20ineffective%20at%20clearing%20pre-existing%20HPV%20infection.%20Here%2C%20two%20recombinant%20Listeria%20strains%20%28LM%5Cu0394-E6E7%20%26%20LI%5Cu0394-E6E7%29%20with%20deletions%20of%20the%20actA%20and%20plcB%20genes%2C%20expressing%20the%20shuffled%20HPV-16%20E6E7%20protein%20were%20constructed.%20The%20strains%20were%20delivered%20into%20the%20spleen%20and%20liver%20by%20intravenous%20inoculation%2C%20induced%20antigen-specific%20cellular%20immunity%20and%20were%20eliminated%20completely%20from%20the%20internal%20organs%20several%20days%20later.%20Intravenously%20treating%20with%20single%20strain%20for%20three%20times%2C%20or%20with%20both%20strains%20alternately%20for%20three%20times%20significantly%20reduced%20the%20tumor%20size%20and%20prolonged%20the%20survival%20time%20of%20model%20mice.%20Combination%20immunotherapy%20with%20two%20strains%20seemed%20more%20effective%20than%20immunotherapy%20with%20single%20strain%20in%20that%20it%20enhanced%20the%20survival%20of%20the%20mice%2C%20and%20the%20LM%5Cu0394-E6E7-prime-LI%5Cu0394-E6E7-boost%20strategy%20showed%20significant%20stronger%20efficacy%20than%20single%20treatment%20with%20the%20LI%5Cu0394-E6E7%20strain.%20The%20antitumor%20effect%20of%20this%20treatment%20might%20due%20to%20its%20ability%20to%20increase%20the%20proportion%20of%20CD8%2B%20T%20cells%20and%20reduce%20the%20proportion%20of%20T%20regulatory%20cells%20%28Tregs%29%20in%20the%20intratumoral%20milieu.%20This%20is%20the%20first%20report%20regarding%20Listeria%20ivanovii-based%20therapeutic%20vaccine%20candidate%20against%20cervical%20cancer.%20Most%20importantly%20we%20are%20the%20first%20to%20confirm%20that%20combination%20therapy%20with%20two%20different%20recombinant%20Listeria%20strains%20has%20a%20more%20satisfactory%20antitumor%20effect%20than%20administration%20of%20a%20single%20strain.%20Thus%2C%20we%20propose%20a%20novel%20prime-boost%20treatment%20strategy.%22%2C%22date%22%3A%222021-06-28%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-92875-9%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-92875-9%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-28T21%3A27%3A49Z%22%7D%7D%5D%7D
Su, L., Zhang, Y., Zhang, X., Liu, T., Liu, S., Li, Y., Jiang, M., Tang, T., Shen, H., & Wang, C. (2021). Combination immunotherapy with two attenuated Listeria strains carrying shuffled HPV-16 E6E7 protein causes tumor regression in a mouse tumor model. Scientific Reports, 11(1), 13404. https://doi.org/10.1038/s41598-021-92875-9 Cite
