Researchers demonstrated that prostaglandin E2 (PGE2) exerted a potent immunosuppressive action during the immune response of the human host against Mycobacterium tuberculosis infection.
[Scientific Reports]
6445212 NNKHSD8Q items 1 apa 0 default asc 1 164084 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-6e34c3d99f250851350229b728b17bea%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22NNKHSD8Q%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Pellegrini%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-30%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EPellegrini%2C%20J.%20M.%2C%20Martin%2C%20C.%2C%20Morelli%2C%20M.%20P.%2C%20Schander%2C%20J.%20A.%2C%20Tateosian%2C%20N.%20L.%2C%20Amiano%2C%20N.%20O.%2C%20Rollandelli%2C%20A.%2C%20Palmero%2C%20D.%20J.%2C%20Levi%2C%20A.%2C%20Ciallella%2C%20L.%2C%20Colombo%2C%20M.%20I.%2C%20%26amp%3B%20Garc%26%23xED%3Ba%2C%20V.%20E.%20%282021%29.%20PGE2%20displays%20immunosuppressive%20effects%20during%20human%20active%20tuberculosis.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%2013559.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-92667-1%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-021-92667-1%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DNNKHSD8Q%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22PGE2%20displays%20immunosuppressive%20effects%20during%20human%20active%20tuberculosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joaqu%5Cu00edn%20Miguel%22%2C%22lastName%22%3A%22Pellegrini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Candela%22%2C%22lastName%22%3A%22Martin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mar%5Cu00eda%20Paula%22%2C%22lastName%22%3A%22Morelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julieta%20Aylen%22%2C%22lastName%22%3A%22Schander%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nancy%20Liliana%22%2C%22lastName%22%3A%22Tateosian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicol%5Cu00e1s%20Oscar%22%2C%22lastName%22%3A%22Amiano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Agust%5Cu00edn%22%2C%22lastName%22%3A%22Rollandelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Domingo%20Juan%22%2C%22lastName%22%3A%22Palmero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alberto%22%2C%22lastName%22%3A%22Levi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorena%22%2C%22lastName%22%3A%22Ciallella%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mar%5Cu00eda%20Isabel%22%2C%22lastName%22%3A%22Colombo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ver%5Cu00f3nica%20Edith%22%2C%22lastName%22%3A%22Garc%5Cu00eda%22%7D%5D%2C%22abstractNote%22%3A%22Prostaglandin%20E2%20%28PGE2%29%2C%20an%20active%20lipid%20compound%20derived%20from%20arachidonic%20acid%2C%20regulates%20different%20stages%20of%20the%20immune%20response%20of%20the%20host%20during%20several%20pathologies%20such%20as%20chronic%20infections%20or%20cancer.%20In%20fact%2C%20manipulation%20of%20PGE2%20levels%20was%20proposed%20as%20an%20approach%20for%20countering%20the%20Type%20I%20IFN%20signature%20of%20tuberculosis%20%28TB%29.%20However%2C%20very%20limited%20information%20regarding%20the%20PGE2%20pathway%20in%20patients%20with%20active%20TB%20is%20currently%20available.%20In%20the%20present%20work%2C%20we%20demonstrated%20that%20PGE2%20exerts%20a%20potent%20immunosuppressive%20action%20during%20the%20immune%20response%20of%20the%20human%20host%20against%20Mycobacterium%20tuberculosis%20%28Mtb%29%20infection.%20Actually%2C%20we%20showed%20that%20PGE2%20significantly%20reduced%20the%20surface%20expression%20of%20several%20immunological%20receptors%2C%20the%20lymphoproliferation%20and%20the%20production%20of%20proinflammatory%20cytokines.%20In%20addition%2C%20PGE2%20promoted%20autophagy%20in%20monocytes%20and%20neutrophils%20cultured%20with%20Mtb%20antigens.%20These%20results%20suggest%20that%20PGE2%20might%20be%20attenuating%20the%20excessive%20inflammatory%20immune%20response%20caused%20by%20Mtb%2C%20emerging%20as%20an%20attractive%20therapeutic%20target.%20Taken%20together%2C%20our%20findings%20contribute%20to%20the%20knowledge%20of%20the%20role%20of%20PGE2%20in%20the%20human%20host%20resistance%20to%20Mtb%20and%20highlight%20the%20potential%20of%20this%20lipid%20mediator%20as%20a%20tool%20to%20improve%20anti-TB%20treatment.%22%2C%22date%22%3A%222021-06-30%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-021-92667-1%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-021-92667-1%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-30T16%3A14%3A32Z%22%7D%7D%5D%7D
Pellegrini, J. M., Martin, C., Morelli, M. P., Schander, J. A., Tateosian, N. L., Amiano, N. O., Rollandelli, A., Palmero, D. J., Levi, A., Ciallella, L., Colombo, M. I., & García, V. E. (2021). PGE2 displays immunosuppressive effects during human active tuberculosis. Scientific Reports, 11(1), 13559. https://doi.org/10.1038/s41598-021-92667-1 Cite