Angiotensin II-Induced Overexpression of Sirtuin-1 Contributes to Enhanced Expression of Giα Proteins and Hyperproliferation of Vascular Smooth Muscle Cells

The authors examined the role of Sirtuin1 (Sirt1) in Angiotensin II (Ang II)-induced overexpression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells (VSMCs). Ang II treatment of VSMCs increased the expression of Sirt1 which was attenuated by AT1 and AT2 receptor antagonists, losartan and PD123319 respectively.