Intranasal plus Subcutaneous Prime Vaccination with a Dual Antigen COVID-19 Vaccine Elicits T-cell and Antibody Responses in Mice

The authors demonstrated subcutaneous prime and SC boost vaccination of CD-1 mice with this dual-antigen vaccine elicits T-helper cell 1 biased T-cell and humoral responses to both spike (S) and nucleocapsid (N) that were greater than those seen with hAd5 S wild type delivering only unmodified S.