AHR Mediates the Aflatoxin B1 Toxicity Associated with Hepatocellular Carcinoma

Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma in individuals infected with the hepatitis virus. AHR-deficient cells tolerated high concentrations of aflatoxin B1 (AFB1), in which AFB1 adduct formation was significantly decreased.