Generation of Bi-Allelic MYBPC3 Truncating Mutant and Isogenic Control from an iPSC Line of a Patient with Hypertrophic Cardiomyopathy

Investigators reprogrammed skin fibroblasts from a hypertrophic cardiomyopathy patient carrying a heterozygous MYBPC3 truncating mutation into human iPSC (hiPSC) and used CRISPR/Cas9 to generate bi-allelic MYBPC3 truncating mutation and isogenic control hiPSC lines.