The Fibronectin-ILT3 Interaction Functions as a Stromal Checkpoint That Suppresses Myeloid Cells

Using a screening approach, the authors identified fibronectin as a functional ligand for immunoglobulin-like transcript 3 (ILT3). The interaction of fibronectin with ILT3 polarized myeloid cells toward a suppressive state, and these effects were reversed with an ILT3-specific antibody that blocked the interaction of ILT3 with fibronectin.