Benign and Malignant Hematologic Manifestations in Patients with VEXAS Syndrome Due to Somatic Mutations in UBA1

Patients with VEXAS syndrome had a propensity toward developing cytopenia, myelodysplastic syndrome, multiple myeloma, and venous thromboembolism. Bone marrow from patients with VEXAS showed characteristic vacuolization of myeloid and erythroid precursors.