An In Vivo Selection-Derived D-Peptide for Engineering Erythrocyte-Binding Antigens That Promote Immune Tolerance

Researchers investigated a straightforward approach based on erythrocyte binding to promote antigen-specific tolerance to both peptides and proteins, and showed that a fully D-chiral peptide library could be selected in vivo for the de novo discovery of a robust erythrocyte binder, which they attached to peptide and protein antigens.