Functional HPV-Specific PD-1⁺ Stem-Like CD8 T Cells in Head and Neck Cancer

Researchers studied CD8 T cells in patients with human papillomavirus (HPV)-positive head and neck cancer and identified several epitopes derived from HPV E2, E5 and E6 proteins that allowed us to analyse virus-specific CD8 T cells using major histocompatibility complex class I tetramers.