mRNA Vaccine-Induced T Cells Respond Identically to SARS-CoV-2 Variants of Concern but Differ in Longevity and Homing Properties Depending on Prior Infection Status

Researchers conducted a longitudinal study of infection-naïve and COVID-19 convalescent donors before vaccination and after their first and second vaccine doses, using a high-parameter CyTOF analysis to phenotype their SARS-CoV-2-specific T cells.