HIF-1–Regulated Expression of Calreticulin Promotes Breast Tumorigenesis and Progression through Wnt/β-Catenin Pathway Activation

Researchers demonstrated that calreticulin facilitated breast cancer progression by promoting the breast cancer stem cell phenotype through Wnt/β-catenin signaling in a hypoxia-inducible factor 1 (HIF-1)–dependent manner.