Combination of Tucatinib and Neural Stem Cells Secreting Anti-HER2 Antibody Prolongs Survival of Mice with Metastatic Brain Cancer

The authors engineered the highly migratory and brain tumor tropic human neural stem cells LM008 to continuously secrete high amounts of functional, stable, full-length antibodies against human epidermal growth factor receptor 2 (HER2) without compromising the stemness of LM008 cells.