GNE-493 Inhibits Prostate Cancer Cell Growth via Akt-mTOR-Dependent and -Independent Mechanisms

A constitutively-active mutant Akt1 restored Akt-mTOR activation but only partially ameliorated GNE-493-induced prostate cancer cell death. Moreover, GNE-493 was still cytotoxic in Akt1/2-silenced primary prostate cancer cells.