Loss of Aryl Hydrocarbon Receptor Suppresses the Response of Colonic Epithelial Cells to IL22 Signaling by Upregulating SOCS3

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Scientists showed that IL22 treatment induced the phosphorylation of STAT3, inhibited colonic organoid growth, and promoted colonic cell proliferation in vivo.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]

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Abstract