Autotaxin Impedes Anti-Tumor Immunity by Suppressing Chemotaxis and Tumor Infiltration of CD8+ T Cells

By
Justin.choi
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0
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Investigators showed that autotaxin (ATC) secreted by melanoma cells was chemorepulsive for tumor-infiltrating lymphocytes and circulating CD8+ T cells ex vivo, with autotaxin functioning as an LPA-producing chaperone.
[Cell Reports]

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