Autotaxin Impedes Anti-Tumor Immunity by Suppressing Chemotaxis and Tumor Infiltration of CD8⁺ T Cells

Investigators showed that autotaxin (ATC) secreted by melanoma cells was chemorepulsive for tumor-infiltrating lymphocytes and circulating CD8+ T cells ex vivo, with autotaxin functioning as an LPA-producing chaperone.