CAR/CXCR5-T Cell Immunotherapy Is Safe and Potentially Efficacious in Promoting Sustained Remission of SIV Infection

Researchers investigated whether infusion of T cells expressing an simian immunodeficiency virus-specific chimeric antigen receptor and the follicular homing receptor, CXCR5, could successfully kill viral-RNA+ cells in targeted lymphoid follicles in SIV-infected rhesus macaques.