The authors studied the contribution of nestin+ bone marrow mesenchymal stem cells to MLL-AF9-driven acute myeloid leukemia development and chemoresistance in vivo.
[Cell Metabolism]
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Forte, D., García-Fernández, M., Sánchez-Aguilera, A., Stavropoulou, V., Fielding, C., Martín-Pérez, D., López, J. A., Costa, A. S. H., Tronci, L., Nikitopoulou, E., Barber, M., Gallipoli, P., Marando, L., Castillejo, C. L. F. de, Tzankov, A., Dietmann, S., Cavo, M., Catani, L., Curti, A., … Méndez-Ferrer, S. (2020). Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.09.001 Cite