Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsResearchers explored whether targeting nitric oxide in estrogen positive breast cancer cells impacts cancer stem cell subpopulation and sensitivity to hormonal therapy with tamoxifen.
[Laboratory Investigation]
6807162 {6807162:GRKSRNJT} apa 50 1 156773 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-de6678849a1f48cc04295b713139aed5%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22GRKSRNJT%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22L%5Cu00f3pez-S%5Cu00e1nchez%20et%20al.%22%2C%22parsedDate%22%3A%222020-12-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EL%26%23xF3%3Bpez-S%26%23xE1%3Bnchez%2C%20L.%20M.%2C%20Mena%2C%20R.%2C%20Guil-Luna%2C%20S.%2C%20Mantrana%2C%20A.%2C%20Pe%26%23xF1%3Barando%2C%20J.%2C%20Toledano-Fonseca%2C%20M.%2C%20Conde%2C%20F.%2C%20De%20la%20Haba-Rodr%26%23xED%3Bguez%2C%20J.%20R.%2C%20Aranda%2C%20E.%2C%20%26amp%3B%20Rodr%26%23xED%3Bguez-Ariza%2C%20A.%20%282020%29.%20Nitric%20oxide-targeted%20therapy%20inhibits%20stemness%20and%20increases%20the%20efficacy%20of%20tamoxifen%20in%20estrogen%20receptor-positive%20breast%20cancer%20cells.%20%3Ci%3ELaboratory%20Investigation%3C%5C%2Fi%3E%2C%201%26%23x2013%3B12.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41374-020-00507-z%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41374-020-00507-z%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3DGRKSRNJT%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Nitric%20oxide-targeted%20therapy%20inhibits%20stemness%20and%20increases%20the%20efficacy%20of%20tamoxifen%20in%20estrogen%20receptor-positive%20breast%20cancer%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%20M.%22%2C%22lastName%22%3A%22L%5Cu00f3pez-S%5Cu00e1nchez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Mena%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvia%22%2C%22lastName%22%3A%22Guil-Luna%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana%22%2C%22lastName%22%3A%22Mantrana%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jon%22%2C%22lastName%22%3A%22Pe%5Cu00f1arando%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marta%22%2C%22lastName%22%3A%22Toledano-Fonseca%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Francisco%22%2C%22lastName%22%3A%22Conde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Juan%20R.%22%2C%22lastName%22%3A%22De%20la%20Haba-Rodr%5Cu00edguez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Enrique%22%2C%22lastName%22%3A%22Aranda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonio%22%2C%22lastName%22%3A%22Rodr%5Cu00edguez-Ariza%22%7D%5D%2C%22abstractNote%22%3A%22Cancer%20stem%20cells%20%28CSCs%29%20are%20involved%20in%20the%20resistance%20of%20estrogen%20%28ER%29-positive%20breast%20tumors%20against%20endocrine%20therapy.%20On%20the%20other%20hand%2C%20nitric%20oxide%20%28NO%29%20plays%20a%20relevant%20role%20in%20CSC%20biology%2C%20although%20there%20are%20no%20studies%20addressing%20how%20this%20important%20signaling%20molecule%20may%20contribute%20to%20resistance%20to%20antihormonal%20therapy%20in%20ER%2B%20breast%20cancer.%20Therefore%2C%20we%20explored%20whether%20targeting%20NO%20in%20ER%2B%20breast%20cancer%20cells%20impacts%20CSC%20subpopulation%20and%20sensitivity%20to%20hormonal%20therapy%20with%20tamoxifen.%20NO%20was%20targeted%20in%20ER%2B%20breast%20cancer%20cells%20by%20specific%20NO%20depletion%20and%20NOS2%20silencing%20and%20mammosphere%20formation%20capacity%2C%20stem%20cell%20markers%20and%20tamoxifen%20sensitivity%20were%20analyzed.%20An%20orthotopic%20breast%20tumor%20model%20in%20mice%20was%20also%20performed%20to%20analyze%20the%20efficacy%20of%20NO-targeted%20therapy%20plus%20tamoxifen.%20Kaplan%5Cu2013Meier%20curves%20were%20made%20to%20analyze%20the%20association%20of%20NOS2%20gene%20expression%20with%20survival%20of%20ER%2B%20breast%20cancer%20patients%20treated%20with%20tamoxifen.%20Our%20results%20show%20that%20targeting%20NO%20inhibited%20mamosphere%20formation%2C%20CSC%20markers%20expression%20and%20increased%20the%20antitumoral%20efficacy%20of%20tamoxifen%20in%20ER%2B%20breast%20cancer%20cells%2C%20whereas%20tamoxifen-resistant%20cells%20displayed%20higher%20expression%20levels%20of%20NOS2%20and%20Notch-1%20compared%20with%20parental%20cells.%20Notably%2C%20NO-targeted%20therapy%20plus%20tamoxifen%20was%20more%20effective%20than%20either%20treatment%20alone%20in%20an%20orthotopic%20breast%20tumor%20model%20in%20immunodeficient%20mice.%20Furthermore%2C%20low%20NOS2%20expression%20was%20significantly%20associated%20with%20a%20higher%20metastasis-free%20survival%20in%20ER%2B%20breast%20cancer%20patients%20treated%20with%20tamoxifen.%20In%20conclusion%2C%20our%20data%20support%20that%20NO-targeted%20therapy%20in%20ER%2B%20breast%20cancer%20may%20contribute%20to%20increase%20the%20efficacy%20of%20antihormonal%20therapy%20avoiding%20the%20development%20of%20resistance%20to%20these%20treatments.%22%2C%22date%22%3A%222020-12-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41374-020-00507-z%22%2C%22ISSN%22%3A%221530-0307%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41374-020-00507-z%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-12-01T17%3A51%3A58Z%22%7D%7D%5D%7D
López-Sánchez, L. M., Mena, R., Guil-Luna, S., Mantrana, A., Peñarando, J., Toledano-Fonseca, M., Conde, F., De la Haba-Rodríguez, J. R., Aranda, E., & Rodríguez-Ariza, A. (2020). Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells. Laboratory Investigation, 1–12. https://doi.org/10.1038/s41374-020-00507-z Cite
