HES1 Promotes Breast Cancer Stem Cells by Elevating Slug in Triple-Negative Breast Cancer

Investigators revealed that HES1 is a novel transcriptional activator for Slug through acting directly on its promoter. HES1 knockdown reduced breast cancer stem cell (BCSC) self-renewal, BCSC population, and cancer cell proliferation in TNBC, whereas overexpression of Slug restored the oncogenic function of HES1, both in vitro and in vivo.