Investigators demonstrated how cyclin-dependent kinase 8 (CDK8) played an essential role in maintaining stemness and tumorigenicity in glioma stem cells.
[Oncogene]
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Fukasawa, K., Kadota, T., Horie, T., Tokumura, K., Terada, R., Kitaguchi, Y., Park, G., Ochiai, S., Iwahashi, S., Okayama, Y., Hiraiwa, M., Yamada, T., Iezaki, T., Kaneda, K., Yamamoto, M., Kitao, T., Shirahase, H., Hazawa, M., Wong, R. W., … Hinoi, E. (2021). CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01745-1 Cite